Vitamin D 3 Receptor As A Target For Breast Cancer Prevention
The vitamin d receptor vdr and its ligand induce a program of gene expression that contributes to maintenance of the differentiated phenotype. This concept predicts that the vitamin d system might impact on both prevention and treatment of breast cancer.
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These studies support the concept that vitamin d protects against tumor development in animal models at both the initiation and promotion stages and offer compelling evidence that the 125oh 2 d 3 and vdr may be important targets for breast cancer prevention.
Vitamin d 3 receptor as a target for breast cancer prevention. The concept underlying the link between vitamin d and breast cancer is fairly simple. The vitamin d 3 receptor vdr is a nuclear receptor that modulates gene expression when complexed with its ligand 1 alpha25 dihydroxycholecalciferol 125oh2 d3 which is the biologically active form of vitamin d 3. Murray a1 madden s2 synnott nc3 klinger r4 oconnor d5 odonovan n6 gallagher w7 crown j8 duffy m9.
Despite the heterogeneous nature of breast tumors with respect to vitamin d signaling exploring the concept of vdr as a therapeutic or preventive target for human breast cancer is warranted. The vitamin d 3 receptor vdr is a nuclear receptor that modulates gene expression when complexed with its ligand 1 alpha25 dihydroxycholecalciferol 125oh2 d3 which is the biologically. The predicted number of new cases of breast cancer in the us exceeds 250000 for 2017.
Vitamin d receptor as a target for breast cancer therapy.
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