Calcium Plus Vitamin D Supplementation And The Risk Of Colorectal Cancer
Against this background the womens health initiative whi designed a trial to test the hypothesis that calcium plus vitamin d supplementation would reduce risk of hip fracture as primary endpoint and of colorectal and breast cancer as designated secondary endpoints among postmenopausal women. However randomized trial evidence that calcium with vitamin d supplementation is beneficial in the primary prevention of colorectal cancer is lacking.
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However randomized trial evidence that calcium with vitamin d supplemen tation is beneficial in the primary prevention of colorectal cancer is lacking.
Calcium plus vitamin d supplementation and the risk of colorectal cancer. Higher intake of calcium and vitamin d has been associated with a reduced risk of colorectal cancer in epidemiologic studies and polyp recurrence in polyp prevention trials. The long latency associated with the development of colorectal cancer along with the seven year duration of the trial may have contributed to this null finding. Title calcium plus vitamin d supplementation and the risk of colorectal cancer abstract background.
Higher intake of calcium and vitamin d has been associated with a reduced risk of colorectal cancer in epidemiologic studies and polyp recurrence in polyp prevention trials. Higher intake of calcium and vitamin d has been associated with a reduced risk of colorectal cancer in epidemiologic studies and polyp recurrence in polyp prevention trials. Daily supplementation of calcium with vitamin d for seven years had no effect on the incidence of colorectal cancer among postmenopausal women.
If the benefit of calcium with vitamin d supplementation is to prevent or slow the progression of colorectal cancer in its early stages and if colorectal cancer has a latency of 10 to 20 years the average intervention and follow up of 7 years in our study may have been insufficient to demonstrate an effect.
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